Tivalosin

• Properties:

Tivalosin is a macrolide antibiotic. Macrolide are metabolites or derivatives of

metabolites of soil organisms obtained by fermentation.

They interfere with protein synthesis by reversibly binding to the 50 S ribosome

subunit.

They are generally considered bacteriostatic.

Tivalosin has activity against pathogenic organisms isolated from a range of animal

species mainly Gram-positive organisms and mycoplasma but also some Gram-negative

organisms.

Tivalosin has activity against Mycoplasma gallisepticumin chickens.

Macrolide (including Tivalosin) have been shown to have effects on the innate immune

system, which may augment the direct effects of the antibiotic on the pathogen and aid

the clinical situation.

Treatment of respiratory disease associated with Mycoplasma gallisepticum inbroiler chickens.

Each 1 gram contains : 972.35 mg. Tivalosin tartrate.

(Eq. to 850 mg Tivalosin base.)

Route of administration: orally via drinking water.

For whole product:

23.5 – 29.4 gm Royaltvalosin85% /1000 kg body weight. For 3-5 days.

1 gm Royaltvalosin85% / 3.4 – 4.2 liters of drinking water. For 3-5 days.

Not authorized for use in laying birds producing eggs for human consumption.

Do not use within 14 days of onset of the laying.

Meat and offal: 5 days.

Broiler Chickens.

No signs of intolerance have been observed in chickens at up to 150 mg tivalosin.

per kg bodyweight per day for 5 days.

Stored at temperature not exceed 30 C˚ in dry place and used immediately after

opening and reconstitution.

White plastic (HDPE) container containing 100 gm sealed with aluminium seal

have company logo lined with (HDPE)plastic film closed by white plastic

(HDPE)cap with an outer lable.