Tilmicosin is a semi-synthetic antibiotic of the macrolide group and is believed to affect protein synthesis. It has bacteriostatic action but at high concentrations it may be bactericidal. This antibacterial activity is predominantly against Gram-positive microorganism with activity against certain gram-negative ones and Mycoplasma of a bovine, porcine, ovine and avian origin. in particular, its activity has been demonstrated against the following microorganism:
Chicken and Turkeys: Mycoplasma gallisepticum and mycoplasma synoviae scientific evidence suggests that macrolides act synergistically with the host immune system. Macrolides appear to enhance phagocyte killing of bacteria. Tilmicosin has been shown to inhibit in vitro the replication of the porcine re productive and respiratory syndrome virus in alveolar macrophages in a dose dependent fashion. Cross-resistance between tilmicosin and other macrolides and lincomycin has been observed.
Chickens & Turkeys: For the treatment and prevention of respiratory disease in chicken flocks, associated with Mycoplasma gallisepticum and M. synoviae.
Each 1ml contain:
278mg Tilmicosin phosphate(Equivalent to 250 mg Tilmicosin)
• DOSAGE & ROUTE OF ADMINISTRATION
Orally via drinking water. For whole product: Chickens (except hens producing eggs for human consumption) 0.6-0.8 ml Tilmicure / Litre of drinking water for 3 days.
• CONTRA – INDICATION
Not authorised for use in laying birds producing eggs for human consumption, Do not use within 14 days of onest of the laying.
• WITHDRAWAL PERIOD
Chickens : 12 days.
Turkeys : 19 days.
• TARGET SPECIES
Chickens (ecept hens producing eggs for human consumption) – Turkeys.
• SIDE EFFECTS
Chicken: No symptoms of overdose have been seen in chickens given drinking water containing levels of tilmicosin 5 times.
The recommended dose for 5 days, daily treatment with 75mg/litre for 10 days resulted in a reduction in faecal consistency.
Stored at temperature not exceed 30 C .