Combivac L

Freeze dried live attenuated Newcastle Disease Virus+

Infectious Bronchitis Virus Vaccine

Newcastle disease is caused by a paramyxovirus. After infection birds begin to show signs of disease as hemorrhage and inflammation of respiratory and intestinal tract.

Infectious bronchitis is caused by coronavirus. Infection causes respiratory pneumonia kidneys infection as well as respiratory tract infection. Combination of both vaccines is efficient due to competing for respiratory receptors sites between vaccine strains and the virus that will moderate the reactions. IB vaccination may be difficult to control if this vaccine is given alone as field boost, the reaction can be moderated by giving the IB vaccine in combination with ND vaccine.

PRESENTATION

Vials of: 1000 doses 

 

INDICATIONS

Combivac L is indicated for vaccination of poultry against Newcastle disease and infectious bronchitis disease, preferable 2-3 weeks of age.

 

COMPOSITION

Freeze dried live attenuated vaccine against Newcastle disease and infectious bronchitis disease in chickens.

Each dose contains at least 106.0 (EID50) Newcastle Disease Virus La Sota strain, and at least 103.5EID50 Infectious Bronchitis Disease Virus H120 strain.

DOSAGE & ROUTE OF ADMINISTRATION

One dose per bird.

Administration:

  • Intraocular/intranasal route:

– Dissolve the vaccine in physiological saline solution (35 ml).

– Administer one drop of the vaccine using a dropper into one eye or nostril.

– Use the vaccine immediately after reconstitution (within two hours in cool conditions).

  • Oral route via drinking water:

– Reconstitute the vaccine with cold pure drinking water, free of antiseptics, and add to it powdered skimmed milk (2 g/L) to stabilize the vaccine’s activity.

– The drinking water temperature containing the vaccine must not exceed 15-20 °C.

– It is advisable to deprive the birds of water 1-2 hours prior to vaccination.

– The vaccine should be given in the early morning or the cool period on a hot day.

– The vaccine should be diluted in adequate quantity of final drinking water in order be consumed within one to two hours after dissolving the vaccine in water according to age of the birds and climatic conditions as follows:

1-7 days of age

Dilute 1000 doses in 5 liters

1-2 weeks of age

Dilute 1000 doses in 10 liters

4-8 weeks of age

Dilute 1000 doses in 20 liters

Above 8 weeks

Dilute 1000 doses in 40 liters

 

  • Aerogenic route via aerosol/spraying.

– Spray the vaccine solution over the birds, at a distance of 30 to 40 cm, using a coarse sprayer producing.

– Close windows, fans and heaters while spraying.

– The necessary quantity of water (distilled water) per 1000 doses are as follows:

– The recommended amount of distilled water per 1000 doses is as follows:

1-7 days of age

200 ml

2 weeks of age

300 ml

4 weeks of age

400 ml

CONTRA-INDICATIONS

None.

 WITHHOLDING PERIOD

None.

SPECIAL PRECAUTIONS:

  • Vaccinate only healthy birds.
  • Deprive birds of drinking water 1-2 hours before vaccination.
  • Apply usual aseptic procedures.
  • Use only clean, antiseptic or disinfectant-free materials for the preparation of the vaccine solution.
  • Unused opened vaccine and waste material should be decontaminated with suitable disinfectants (phenolics, idophores or formal aldehydes) at the recommended concentration.
  • Avoid human exposure to the vaccine.

STORAGE & SHELF LIFE

Store between +2 °C to +8 °C and protect from sun light.

The vaccine remains stable for 2 years from production date stated on the label under the recommended storage conditions.