Devacox is a coccidiocidal drug, water soluble powder, containing ”Sulphadimidin Sodium & Diaverdine Hydrochloride”. Sulphadimidin is a pyrimidine sulfonamide, antibacterial agent. Sulphonamide, being structural analogues of Para-amino benzoic acid (PABA), competitively inhibit the incorporation of PABA into dihydropteroic acid the precursor of folic acid. Subsequent reduction in the level of folic acid reduced the production of nucleic acid in sensitive bacteria. Sulphadimidin act on the asexual stages of coccidia by interfering with the production of folic acid. Diaviridine is a folic acid antagonist which act by making inhibition to the dihydrofolate reductase enzyme. Sulfonamides are often used in combination with dihydrofolate reductase inhibitors because of the observed synergistic effects due to activity at two places in folate biosynthesis
Devacox is used in chickens, turkeys, rabbits, calves and lambs for treatment of Coccidiosis.
Each 100 gm contain:
Sulphadimidin Na: 86.3 gm (Eq. to 80 gm Sulphadimidin base)
Diaverdine Hcl : 2.8 gm (Eq. to 2.5: gm Diaverdine base)
Orally via drinking water
Poultry ,rabbits & turkeys: 1/2 gm Devacox / liter of drinking water once daily for 3 days rest for 2 days then repeat the same dose for 3 days.
Calves and lambs: 1gm Devacox / 5 kg. b.w. for 4 successive days
• WITHDRAWAL PERIOD
Meat: 10 days Egg:12 day
Calves and lambs: 21 days
Store dry, in a well closed packing, below 30oC and protected from light.